Palace trail 11th-placed Brighton and Hove Albion by seven points with eight games remaining in the campaign, meaning a few adverse results could drag any of the teams in the bottom half of the table into the relegation battle.
"Every game will be a massive game, it is not helpful to build games up as 'win at all costs'. We know, and Huddersfield know, the importance of the game," Hodgson told reporters on Thursday.
"This year is exceptional. Normally there's at least three groups in the table: the top 6 or 7, another 6 or 7 and then the bottom teams. There's not much between the bottom half this season. But this will be a tough period in these last eight games."
Hodgson said that Palace were not focused on avenging their opening day 3-0 home league defeat by Huddersfield but instead on getting a vital win.
Palace winger Wilfried Zaha returned to action from a knee injury in last Saturday's 2-1 league defeat by Chelsea while midfielder Yohan Cabaye, on-loan striker Ruben Loftus-Cheek and defender Mamadou Sakho returned to training this week.
"It's been good to get players back from injury this week. We're looking at a fuller squad, if not a full squad," Hodgson added.
"Our work rate and our running distances have been good in every game lately. I'll be expecting the same energy levels and enthusiasm from everybody, especially those returning from injury."
Hodgson also dismissed the notion that games against fellow strugglers would matter more than those against top-half opposition during the run-in.
Palace will be eager to bounce back from consecutive league defeats to Everton and top-five sides Tottenham Hotspur, Manchester United and Chelsea.
(Reporting by Aditi Prakash in Bengaluru, editing by Pritha Sarkar)
