"We've got to go there and get a positive result. The bare minimum is a good performance for the travelling fans and to be positive in our outlook," Hughes told reporters on Friday.
Relegation-threatened Southampton were thumped 3-0 at West Ham United in their last outing and sit 18th in the table with 28 points from 31 games.
"I expect a reaction from the team," Hughes, who took over from the sacked Mauricio Pellegrino last month, added.
"We need to be more resilient when the momentum goes against us. I've told them (the players) this week what is acceptable in games and what isn't."
Midfielder Mario Lemina returned to training on Friday after an illness this week and faces a late test to be ready.
Arsenal are sixth in the league with 51 points.
(Reporting by Shrivathsa Sridhar in Bengaluru, editing by Pritha Sarkar)
