India captain Virat Kohli has won the toss and chosen to bat as the tourists look to seal the series in the fourth one-day international against South Africa.
India has been dominant so far, winning every game by a big margin to lead the six-game contest 3-0.
India made its first team change of the series at the Wanderers, a move forced by a hamstring injury to allrounder Kedar Jadhav.
Batsman Shreyas Iyer came into the team in his place.
South Africa is boosted by the return of AB de Villiers, who has recovered from a finger injury to play his first game of the series.
De Villiers replaced Khaya Zondo and South Africa also recalled pace bowler Morne Morkel in place of spinner Imran Tahir.
Lineups:
South Africa: Aiden Markram (captain), Hashim Amla, AB de Villiers, JP Duminy, Heinrich Klaasen, David Miller, Chris Morris, Andile Phehlukwayo, Kagiso Rabada, Morne Morkel, Lungi Ngidi.
India: Virat Kohli (captain), Rohit Sharma, Shikhar Dhawan, Ajinkya Rahane, Mahendra Singh Dhoni, Shreyas Iyer, Hardik Pandya, Bhuvneshwar Kumar, Kuldeep Yadav, Jasprit Bumrah, Yuzvendra Chahal.
