In an interview with CNN to mark 100 days in office, Mr Joko says Indonesia's drugs problem needs a serious approach.
"Imagine, every day we have 50 people die because of narcotics, because of drugs," he said.
"In one year, it's 18,000 people who die because of narcotics.
"We are not going to compromise for drug dealers.
"No compromise. No compromise."
Mr Joko said it was the courts that determined death sentences, and the condemned could ask him for clemency.
"But I tell you, there will be no amnesty for drug dealers," he said.
Asked if that meant no relief for the Australians, Mr Joko just shook his head.
The first six of 64 drug offenders on death row were sent to the firing squad last week.
Chan and Sukumaran have already received Mr Joko's rejection of their clemency, and could be next.
Authorities will this week evaluate the first executions before setting a date for the next round.
Those executions prompted Brazil and The Netherlands to withdraw their ambassadors in protest after their pleas to save their citizens were ignored.
Australia could take the same step if Chan and Sukumaran are killed.
Prime Minister Tony Abbott says the government will continue pleading the men's case, as they are rehabilitated and deserve mercy.
Lawyers for Chan and Sukumaran expect to file a final court challenge to their death sentences this week.
Indonesia's representative on ASEAN's human rights commission regrets his country has regressed on the death penalty, missing a chance to lead in the region.
Rafendi Djamin says Indonesia could be encouraging its neighbours Singapore, Thailand, Vietnam and Malaysia towards abolishing capital punishment, "but now, it's like we're refusing to lead the way".
A long-time rights advocate internationally, Mr Djamin told AAP Indonesia has also taken the recall of the two ambassadors too lightly.
"This was not some random act," he said of the diplomatic retreats.
"The fact that the king of (The Netherlands) makes efforts to save one of his citizens and then recalls his ambassador, that's something serious."
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