An MRI scan revealed a small fracture on the former world champion's lower leg which might be related to his crash at La Fleche Wallonne classic race in April.
"I know with these problems, I can maybe go to the Tour, but not at 100 percent," Belgian Gilbert said in a statement.
"So at this point, I have to make a choice to skip the Tour. My first objective is to feel healthy again and not feel the pain any more."
(Reporting by Andrew Callus, editing by Ed Osmond)
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