Wales, who top their qualification group after they beat Moldova 4-0 earlier this month, will travel to take on Austria on Oct. 6 and then return to Cardiff City Stadium to face Georgia on Oct. 9.
"It's a huge disappointment that we won't have Rambo. For 30 percent of our campaign will now be without our best player," Coleman, who guided the country to the Euro 2016 semi-finals, told reporters on Thursday.
"It's disappointing he's not fit when we expected him to be fit. He expected to be fit sooner as well so it's disappointing for all of us."
In light of the recent corruption crisis that has hit English football, which led to the resignation of England manager Sam Allardyce on Tuesday, Coleman called for a zero tolerance policy against those found guilty of corruption.
"It's naive of anyone to think there is no corruption in football because it's everywhere. It's not about class or how much you earn... Now it's bungs in football and we've seen the stuff at FIFA," the 46-year-old said.
"It's sad but I have zero respect for anyone caught because it is people stealing money. If anyone is caught, then they should be removed from the game permanently and that's it, good night."
(Reporting by Shravanth Vijayakumar in Bengaluru, editing by Pritha Sarkar)
