The England international is likely to be out for about six months after he was injured under a challenge from defender Hector Moreno as he stormed into the penalty area in the 15th minute.
The 20-year-old, who was carried off on a stretcher with an oxygen mask strapped to his face, reportedly went under the knife twice before he was brought back to England.
The former Southampton defender had been in impressive form for club and country after a difficult first year at Old Trafford, but now faces a race against time to be fit for the European Championship in France next year.
(Reporting by Shravanth Vijayakumar in Bengaluru; editing by Sudipto Ganguly)
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