Ireland flanker Jordi Murphy, who scored the first try in Saturday's historic triumph over New Zealand, will be sidelined for up to nine months with a knee injury.
"Jordi Murphy leaves the squad after damaging the ACL in his left knee which rules him out of action for between 6-9 months," the IRFU said on its website.
The 25-year-old's try set Ireland on the way to a 40-29 win in Chicago, their first success over the All Blacks in 29 Tests which ended the world champions' record 18-match winning streak.
As well as missing upcoming Tests against New Zealand and Australia in Dublin, the injury will see him miss next year's Six Nations.
Ireland have added six players to their original 34-man squad - Niyi Adeolokun, Tiernan O'Halloran (Connacht), Dave Kilcoyne, Jack O'Donoghue, Darren Sweetnam (Munster) and Dan Leavy (Leinster) - as they prepare to host Canada on Saturday.
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