Australian John Millman has suffered an upset in the second round of the New York Open, losing to Guillermo Garcia-Lopez in a tight three-setter.
The world No.102 Spaniard broke the fourth seed's serve just once on his way to a gutsy 7-6 (7-4) 1-6 6-4 victory in two hours and 11 minutes.
It leaves Jordan Thompson as the only Australian left in the ATP 250 event after booking a quarter-final clash with big-serving American John Isner, who beat Bernard Tomic in straight sets.
Frances Tiafoe lost his first match since the Australian Open quarter-finals, falling to Jason Jung of Taiwan 6-3 7-5.
Tiafoe was the No. 2 seed after accepting a wild card into the field and had a first-round bye.
The American has a career-high ranking of No. 29 after his run in Melbourne, where he lost to Rafael Nadal.
Two other Americans reached the quarterfinals. No. 6 seed Sam Querrey, a finalist last year on Long Island, beat Radu Albot of Moldova of 6-3 6-4.
Reilly Opelka advanced when Denis Istomin of Uzbekistan was forced to retire after they split a pair of tiebreakers.
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