London Marathon winner Jeptoo trailed last year's New York runner-up Deba, who lives and trains in the Big Apple, by nearly four minutes before shifting into catch-up mode from the 16-mile mark to reel in her rival.
The win brought Jeptoo a World Marathon Majors bonus of $500,000 in addition to the New York prize of $100,000.
Deba finished second, 49 seconds back on a windy, chilly day in a race run under tight security in the aftermath of the Boston Marathon bombings.
(Reporting by Larry Fine; editing by Tony Jimenez)
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