Kieran Powell (12) and Evin Lewis (33) fell to the leg-spinner before he later sent number six Roston Chase on his way for nine.
West Indies, led by an unbeaten 48 from Shai Hope, won with 64 balls to spare and four wickets in hand. They scored 138/6 off 39.2 overs, in reply to Afghanistan's all out for 135 off 37.3 overs.
The final game of the series will be played in St. Lucia on Wednesday.
(Reporting by Andrew Both in Cary, North Carolina; Editing by Peter Rutherford)
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