"If I had the choice to watch a Champions League game on Wednesday I would watch this one," Klopp told reporters.
"I think it's really not... it is about tactics but there will be fire in the game, so that's cool. And it's at Anfield anyway, so a good atmosphere to watch."
Liverpool suffered a 5-0 league defeat at the Etihad Stadium in September after forward Sadio Mane was sent off but exacted their revenge with a 4-3 win at Anfield in January, which remains City's only Premier League defeat of the season.
Despite the defeat, Pep Guardiola's side remain 16 points clear at the top of the standings and Klopp accepts it will be difficult to knock City out over two legs in Europe.
"Did we think before the first game we would lose 5-0? No. Did we think before the second we would win 4-3? No. But do we know we have a chance? Yes," he added.
"Actually that was clear before but they are the favourites. We should finish the game with 11 first of all, that would be cool. We know it's difficult.
"At specific moments we are on a similar level but they have been much more consistent and that's why they are higher in the league. We see our chance but we know it will be unbelievably difficult."
Both teams warmed up for the tie with away league wins over the weekend as Liverpool cemented their third-place position in the table with a 2-1 triumph at Crystal Palace, while City eased to a 3-1 victory over Everton at Goodison Park.
(Reporting by Hardik Vyas in Bengaluru)
