"He is currently in a brace and on crutches and is expected to be out of action for between six to eight weeks," the Auckland side said in a statement.
The nuggety 22-year-old had been in strong form for the Blues and was rated a candidate to start against England in the three-test series.
Piutau's injury opens the door for a recall for the versatile Colin Slade, who has been the forgotten man of New Zealand rugby, playing only one test since the 2011 World Cup.
The 26-year-old, once considered heir apparent to flyhalf Dan Carter, has performed solidly for the Crusaders in Super Rugby and may be in line for a recall when All Blacks coach Steve Hansen names an extended 35-man squad this week.
The New Zealand squad convenes for two training camps in Christchurch (May 18-20) and Wellington (May 25-27) before the opening test against England at Eden Park on June 7.
(Reporting by Ian Ransom; Editing by Patrick Johnston)
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