It's adios to Tasmania's three amigos.
The Tasmanian Liberals are no longer a force in the federal lower house, after Andrew Nikolic, Brett Whitely and Eric Hutchison lost their seats to Labor.
Incumbent independent MP Andrew Wilkie, who attracted a swing of more than six per cent in the Hobart electorate of Denison, is the sole aberration among the ALP's new stranglehold in the island state.
Labor's Julie Collins has been returned for a fourth term in Franklin with a swing of more than seven per cent, while Brian Mitchell, Ross Hart and Justine Keay have secured Lyons, Bass and Braddon, respectively.
"It looks like I will no longer be the only (Tasmanian) Labor member in the House of Representatives," Ms Collins told the party faithful in Hobart on Saturday night.
The result means the end of one-term Liberals Eric Hutchinson, Andrew Nikolic and Brett Whiteley - the self-titled "Three Amigos".
Mr Wilkie cited dissatisfaction in the community with the coalition government under prime ministers Malcolm Turnbull and Tony Abbott.
"The Turnbull government has time and time again let Tasmania down," he told reporters.
"Sure, at the last minute there were a whole lot of pork-barrelling promises to tame Bass, Braddon and Lyons, but frankly it was too late because it was already clear ... that Malcolm Turnbull doesn't have Tasmania on his map of Australia."
Senior Liberal senator Eric Abetz said Labor's scare campaign on the privatisation of Medicare, along with the coalition's policy on superannuation meant his party's MPs and candidates were swamped by issues out of their control.
"The Medi-scare campaign was unfortunately very effective in Tasmania on the basis that we are a welfare-dependent state and that did unfortunately cut through," he told AAP.
"Medi-scare was a dishonest campaign so (Labor) have achieved a higher vote than would have been expected on the back of a lie."
With no Liberal MPs in Tasmania, Senator Abetz said the state would be left to rely on the work of the party's senate team under a coalition government, which would be a tough task.
Mr Mitchell said protecting Medicare would be front and centre of his work in Canberra.
"The No.1 issue in (Lyons) is Medicare and fairness," he said.
"And very close behind is that people have a real sense of despondency about the state of politics in this country. They want more unity, they want more stability, they want politicians to stop playing games and get on with business."
Tasmania's senate results could take several weeks to finalise but early counts show four spots for each for the coalition and Labor, one to the Greens and the return of Jacqui Lambie, with two positions to be decided.
