Hull, who beat champions Leicester on the opening day of the season, took the lead when Sam Clucas bundled home after Kasper Schmeichel could only parry Kamil Grosicki's cross in the 14th minute.
Buoyed by their impressive 3-1 victory over Liverpool on Monday, Leicester equalised in the 27th minute through defender Christian Fuchs who exchanged passes with Jamie Vardy before stroking home.
Riyad Mahrez scored Leicester's second in the 57th minute before Tom Huddlestone's own goal in the 91st minute ended a good week for Leicester. The Foxes, now 15th, have 27 points - six points above 19th-placed Hull.
(Reporting by Tom Hayward, editing by Ed Osmond)
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