Defending champion Alex Noren of Sweden, who shot 67, and Nicolas Colsaerts (70) were Fitzpatrick's closest challengers.
Belgian Colsaerts had wiped out Fitzpatrick's overnight advantage by the mid-point of his round, holing three birdies to match the Briton's 11 under par at the turn.
But their fortunes changed on the first of the back nine, Colsaerts dropping a shot while his playing partner made birdie.
Then, at the par-five 13th, the 21-year-old Fitzpatrick, who claimed his first European Tour victory in the British Masters last October, conjured up a brilliant recovery while Colsaerts missed his par putt after finding the water.
England's Lee Westwood, a former world number one, failed to make a move and remained five under after including a double-bogey in a round of 72.
Swede Henrik Stenson, the world number six, picked up two shots to card a 70 and finish on four under.
(Reporting by Neville Dalton, editing by Ed Osmond)
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