Lille's Marvin Martin was sent off in the 37th minute for an awful tackle on France midfielder Yohan Cabaye which saw the former Newcastle United player carried off on a stretcher, and were 1-0 down soon after when Brazil's Marquinhos headed home.
Lucas Moura doubled the lead for PSG, who won their second straight title on Wednesday despite losing to Stade Rennes, after 65 minutes and Blaise Matuidi added a third before Jonathan Delaplace got a consolation for the hosts in the 90th.
Lille's first loss in 14 games leaves them with a two-point lead over St Etienne, who won 3-1 at Nantes, in the race for the Champions League playoff spot with one round of matches left.
Second-placed AS Monaco moved on to 79 points with a 2-1 win at Valenciennes thanks to Nabil Dirar's 87th minute strike after Valere Germain gave them the lead five minutes before halftime, with Tongo Doumbia equalising for the hosts in the 70th.
(Reporting by Josh Reich; editing by Ken Ferris)
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