The Rebels were competitive in the opening half and only trailed 14-10 at the break but they faded badly in the second period, not helped by a yellow card for number eight Scott Higginbotham.
Lions scored three tries through wing Anthonie Volmink, flanker Warwick Tecklenburg and number eight Warren Whiteley.
Flyhalf Marnitz Boshoff, who last month made his Springbok debut, kicked five penalties and two conversions.
The visitors picked up tries from wing Tom English and loose forward Colby Fainga'a, with fullback Jack Debreczeni converting both and booting a penalty.
(Reporting by Nick Said; editing by Tony Jimenez; nick.said@thomsonreuters.com +27832722948 Messaging nick.said.thomsonreuters.com@reuters.net; To sign up for our Global Sports Forum chatroom, click on https://forms.thomsonreuters.com/global_sports_forum)
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