Tests on Monday revealed Luci has torn the anterior cruciate ligament in his left knee and the club says "the season can be considered over for him."
The 28-year-old midfielder had to be replaced in the 31st minute of Livorno's 2-1 win at Cagliari on Sunday.
The news is a blow to Livorno's survival hopes.
Livorno lies 17th in the Serie A, just one point above the relegation zone.
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