Lucky loser Popyrin out of New York Open

Lucky loser Alexei Popyrin has been bundled out of the New York Open with a straight sets first-round defeat to Spain's Guillermo Garcia-Lopez.

Australia's Alexei Popyrin was unable to make the most of his lucky break at the New York Open. (AAP)

Alexei Popyrin has been unable to capitalise on a lucky loser spot in the ATP's New York Open, falling to Spain's Guillermo Garcia-Lopez in the first round.

Replacing American Bradley Klahn in the main draw, Australian teenager Popyrin spurned three chances to take the first set in a tiebreaker and never recovered in the 7-6 (8-6) 6-3 defeat in an hour and 22 minutes.

Australian fourth seed John Millman will be Garcia-Lopez's next opponent in the round of 16.

In other first-round results, American Reilly Opelka upset fifth-seeded Frenchman Adrian Mannarino 2-6 7-6 (7-5) 6-4 while Taiwan's Jason Jung and qualifier Christopher Eubanks also won through to the second round.