Yassine Benzia, 18, levelled in the 39th minute with his first league goal of the season.
It only took 10 minutes either side of halftime for Lyon to wrap up the match thanks to Alexandre Lacazette's third goal of the season in the 44th minute and a splendid 20-metre curling strike from Yoann Gourcuff four minutes after the interval.
Champions Paris St Germain, who drew 1-1 at Montpellier in their season opener, take on Ajaccio on Sunday. Monaco host Montpellier earlier the same day.
(Reporting by Gregory Blachier; Editing by Tony Goodson)
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