"Sporting director Rouven Schroeder and head coach Sandro Schwarz absolutely convinced me about the path Mainz is on," Fischer said in a statement.
"I want to become a part of this team and this club quickly, find my form and show my qualities as an attacking player."
Fischer, who is capped 15 times by Denmark, scored 24 goals in 79 appearances for Ajax between 2012 and 2016.
(Reporting by Hardik Vyas in Bengaluru; Editing by Peter Rutherford)
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