Delph was suspended for three games after his dismissal in the 1-0 FA Cup fifth round loss at Wigan Athletic last month and missed Wednesday's 2-1 Champions League last 16 second leg defeat by Swiss side Basel with a muscle injury.
"Some of them are better. Fernandinho and Sterling are much better. Fabian Delph is like this, like that (uncertain)," Guardiola told reporters on Friday.
"We have training sessions to decide before the game. Today, the players are off, so I don't exactly know the situation."
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Leaders City have 78 points with nine games left and need four wins to wrap up their first league title under Guardiola. They also have a chance to become the first team to break the 100-points barrier in the history of the English top flight.
"I know everyone wants to anticipate the situations, when we will win the title. The best example is two days ago, we lost against Basel," said Guardiola, whose side reached the Champions League quarter-finals with a 5-2 aggregate victory over the Swiss club.
"Just be relaxed, be calm and focus on Stoke."
Paul Lambert's relegation-threatened Stoke are 19th in the table with 27 points. They suffered their heaviest defeat of the current campaign at the Etihad Stadium earlier this season when they were beaten 7-2 by City.
(Reporting by Shrivathsa Sridhar in Bengaluru, editing by Pritha Sarkar)
