City have lost just one league game at home this season and play three of their four remaining league games at the Etihad Stadium.
"Our qualification depends in our home at the Etihad with the three games that we have," Guardiola said.
"We have tough games. Everybody has tough games so it's game by game."
City host a resurgent Crystal Palace, who defeated three of the league's top six in April, on Saturday before visits by champions Leicester City and eighth-placed West Bromwich Albion. They end their season at Watford on May 21.
(Reporting by Aditi Prakash in Bengaluru; editing by Amlan Chakraborty)
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