With United fifth in the league table, six points off the top-four, the 30-year-old striker recently said that winning the Europa League or the FA Cup could save their disappointing season.
Combative midfielder Marouane Fellaini was another notable absentee and full back Matteo Darmian will not be involved after dislocating his shoulder during Saturday's 2-1 league defeat by Sunderland.
United manager Louis van Gaal picked a young squad to face Midtjylland, including Regan Poole, Joe Riley and James Weir who could make their first-team debuts.
(Reporting by Shravanth Vijayakumar in Bengaluru, editing by Ed Osmond/Toby Davis)
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