Manchester United will have to subdue another potential giant-killer after the record 11-time FA Cup winners were handed a fourth-round trip to League Two minnows Cambridge United.
Louis van Gaal's team were paired with the lowest ranked team left in Monday's draw and will head to the tiny Abbey Stadium on the weekend of January 24-25.
A total of 79 league places separate Richard Money's side with van Gaal's star-studded line-up, who avoided an embarrassing third-round defeat at League One outfit Yeovil on Sunday with a 2-0 win.
Holders Arsenal will also be hoping to avoid an upset when they travel to Championship team Brighton.
Manchester City host Championship promotion contenders Middlesbrough after beating Sheffield Wednesday, another second tier team, on Sunday.
Chelsea could face a feisty London derby against Millwall at Stamford Bridge if the Lions come through their replay with Bradford City.
Sheffield United's reward for their shock 3-0 win over QPR on Sunday is a trip to fellow third-tier side Preston.
FA CUP DRAW
Southampton or Ipswich v Crystal Palace
Cambridge United v Manchester United
Blackburn v Swansea
Chelsea v Millwall or Bradford
Derby v Scunthorpe or Chesterfield
Preston v Sheffield United
Birmingham v West Brom
Aston Villa v Bournemouth
Cardiff v Reading
Liverpool v Bolton
Burnley or Tottenham v Leicester
Brighton v Arsenal
Rochdale v Stoke
Sunderland v Fulham or Wolves
Doncaster or Bristol City v Everton or West Ham
Manchester City v Middlesbrough
Ties to be played across the weekend beginning January 24.
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