Versatile England international Jones was left out of United's 1-0 victory over Tottenham Hotspur at Old Trafford on the opening day of the Premier League season and tests confirmed he is suffering from blood-clotting problems.
"It has now been revealed that Jones has mild thrombosis and the blood clotting has forced him to be sidelined for the opening of the campaign," a club statement said.
"Consequently, the centre-back is expected to miss the two Champions League play-off ties with Club Brugge."
The 23-year-old is expected to also miss league games against Aston Villa, Newcastle United and Swansea City as well as the home and away clashes against Brugge.
(Reporting by Martyn Herman, Editing by Ian Chadband)
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