Peyton Manning went virtually untouched by Kansas City's defence on Sunday, throwing for 323 yards and a touchdown to lead the Denver Broncos to a 27-17 victory over the NFL's last undefeated team.
The Chiefs, who came into the game with a league-leading 36 sacks, barely breathed on Manning, who finished 24 for 40.
The Broncos equalled Kansas City at 9-1 atop the American Football Conference West with a rematch set in two weeks.
Alex Smith threw for 230 yards and two touchdowns for Kansas City, which hadn't lost since a 38-3 setback in Denver last December to close out a 2-14 season.
Meanwhile, the Chicago Bears downed the Baltimore Ravens 23-20 after Robbie Gould kicked a 38-yard field goal in a game delayed about two hours by a torrential downpour.
Justin Tucker levelled it for the Ravens with a 21-yard field goal at the end of regulation.
The big delay came after Tucker kicked a 52-yard field goal with 4:51 remaining in the first quarter. Fans were ordered to take cover. Players headed to the locker rooms as heavy rain and winds whipped through Soldier Field.
They emerged about two hours later with the sky clearing and the sun coming out, but the rain and wind returned in the third quarter, turning the stands into a sea of ponchos.
Marques Colston capped a record-setting day with a 20-yard reception to get the Saints into field goal range and Garrett Hartley kicked a 31-yarder as time expired to lift New Orleans over the San Francisco 49ers 23-20.
Hartley, who had missed four field goals in the Saints' previous three games, made all three of his field goal attempts in the fourth quarter - he earlier hit from 21 and 42 yards.
Colston finished with five catches for 80 yards to become the Saints' all-time leader in yards receiving with 7,923, passing Eric Martin's two-decade-old mark of 7,854.
At Philadelphia, Nick Foles threw for 298 yards and ran for a touchdown, and LeSean McCoy had two TDs rushing as the Eagles broke a 10-game home losing streak with a 24-16 win over the Washington Redskins.
Cincinnati posted a 41-20 win over Cleveland; the Pittsburgh Steelers rallied to beat the Detroit Lions 37-27, while Jairus Byrd had two interceptions to lead a Buffalo defence that forced four turnovers in a 37-14 victory over the New York Jets.
In other games, Oakland beat the Houston Texans 28-23; Arizona beat the Jacksonville Jaguars 27-14; the Tampa Bay Buccaneers downed the Atlanta Falcons 41-28, the New York Giants defeated the Green Bay Packers 27-13, the Seattle Seahawks crushed the Minnesota Vikings 41-20 and the Miami Dolphins were 20-16 winners over the San Diego Chargers.
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