"Apologies to everyone at @valerotxopen for my withdrawal," McDowell, whose only major victory came at the 2010 U.S. Open, tweeted.
"Strained my lower left leg/ankle area practicing y/day and played with heavy strapping on it in the pro am and this morning. With The Masters upcoming I decided that getting fit is imperative. Don't like WDs."
McDowell, 35, is scheduled to play in next week's Houston Open as his final tune-up event before the April 9-12 Masters, the first of the year's four majors.
(Reporting by Mark Lamport-Stokes in Los Angeles; Editing by Frank Pingue)
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