As they tried to break up an attack, Lille midfielder Anwar El-Ghazi inexplicably passed to Monaco striker Jovetic on the edge of the area and he rifled the ball home in the 24th minute for his first goal since joining the club from Inter Milan in the summer window.
Monaco needed no help from their hosts six minutes later as Ghezzal arrived late into the box to slam the ball home with his left foot after a sweeping move down the right.
Radamel Falcao netted a simple header three minutes into the second half, nodding the ball into an empty net after Mike Maignan blocked the initial shot by Rony Lopes, and he added a penalty in the 74th minute.
The win puts Monaco on 18 points and in second place on goal difference behind PSG, who visit Montpellier on Saturday.
(Reporting by Philip O'Connor; Editing by Toby Davis)
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