In a statement on the club's Twitter feed, Monaco confirmed that Boschilia had a twisted right knee and had ruptured the anterior cruciate ligament. It said he will undergo surgery in the coming days.
"It's a serious injury and his season might be over," Monaco coach Leonardo Jardim told reporters on Saturday.
"He's an important member of our squad, capable of playing in three positions and very good at set pieces.
"I would have preferred to have won 1-0 (against Metz) and kept Gabriel."
Monaco are on 58 points after 25 matches, three ahead of second-placed Paris St Germain. The principality club last won the Ligue 1 title in 1999-2000.
They are also in the last 16 of the Champions League where they will face Premier League side Manchester City.
(Reporting by Ed Dove; editing by Martyn Herman)
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