Muguruza converted all of her six break points to set up a meeting with either Russian 24th seed Anastasia Pavlyuchenkova 2009 champion Svetlana Kuznetsova.
After an early exchange of breaks, the 22-year-old Muguruza, a quarter-finalist at Roland Garros in the last two years, found her groove and won the last nine games on a sun-drenched Court Philippe Chatrier.
She ended the world number 54's ordeal with an exquisite backhand dropshot on her first match point.
(Reporting by Julien Pretot,; Editing by Pritha Sarkar)
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