The Spaniard, seeded fourth, will play his opening match in Paris on Court Suzanne Lenglen, and not the main Philippe Chatrier showcourt where he lifted the Musketeers Cup for the ninth time in 2014.
Paire has his fans, including 2015 champion Stan Wawrinka, who describes the Frenchman as a "very talented" player who "does a lot of things very well".
Nadal, however, has been in imperious form this season, losing only one match on clay.
Defending champion Novak Djokovic is second on Chatrier in what could be a taxing outing against claycourt specialist Marcel Granollers.
Opening proceedings on the main court is defending champion Garbine Muguruza. The out-of-form Spaniard faces a tricky encounter against 2010 winner Francesca Schiavone of Italy.
If she loses, Muguruza will become only the second female defending champion to exit the tournament in the first round after Russian Anastasia Myskina in 2005.
Rising talent Alexander Zverev, the ninth seed from Germany, takes on Spain's Fernando Verdasco, while home favourite Kristina Mladenovic, a finalist in Stuttgart and Madrid this year, faces American Jennifer Brady.
(Reporting by Julien Pretot, editing by Pritha Sarkar)
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