World number one Rafael Nadal suffered his first defeat in Barcelona since 2003 on Friday when compatriot Nicolas Almagro ended his 41-match winning run in the Spanish city.
Top seed Nadal, the eight-time champion, lost 2-6 7-6 (7-5) 6-4 to Almagro in a quarter-final lasting 13 minutes short of three hours.
Nadal, who lost in the Monte Carlo Masters quarter-finals to David Ferrer last week, had last been beaten in Barcelona when he was just 15 years old.
Despite the defeat, 27-year-old Nadal refused to panic with the defence of his French Open crown starting in just a month's time.
He said losing a tennis match was nothing in comparison to the death of former Barcelona football coach Tito Vilanova who lost his battle with cancer at the age of 45 on Friday.
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"To lose is not a drama. What has happened to Tito Vilanova is. We are left with his example and I send my support to his family," said Nadal.
He added: "I was better in parts of the match, but sport is like that. It was my turn to lose and I congratulate Nico."
Nadal will next defend his Madrid and Rome Masters claycourt titles - two of the 10 tournaments he won in 2013 after a seven-month injury lay-off.
Friday's victory was 28-year-old Almagro's first over Nadal in 11 meetings, a series which included a straight-sets loss in the 2013 Barcelona final.
He needed two match points to secure his shock triumph while surviving 47 unforced errors. The sixth seed had also been a break down in the deciding set.
Nadal's last defeat at the tournament was in the second round to compatriot Alex Corretja in 2003 before he skipped the 2004 event through injury.
His loss of the second set to Almagro on Friday was the first he had dropped at the Real Club de Tenis since 2008, ending a run of 44 consecutive sets.
"Winning the last point I felt happy for all of my team," said Almagro who broke Nadal three times in the final set.
He had trailed 3-1 in the decider and had been 3-1 down in the second set tiebreaker.
"This victory could mark a turning point in my career. Now I need to prepare for tomorrow's match."
Almagro, the world number 20, will face Santiago Giraldo of Colombia for a place in the final.
Giraldo went through when Germany's Philipp Kohlschreiber retired with a left thigh injury while trailing 4-3 in the second set having dropped the first 6-4.
Japan's Kei Nishikori continued his impressive return to action after a three week absence due to a groin injury as he beat 12th seed Marin Cilic 6-1 6-3.
The fourth seed will next play Latvian ninth seed Ernests Gulbis who secured a third semi-final appearance of the season with a 6-1 6-4 win over Russia's Teimuraz Gabashvili.
