Nishikori, who accepted a late wild card into the ATP World Tour 250 event, is looking to get his clay-court season going ahead of the French Open after a third-round exit in Rome last week. A wrist injury kept him out of Barcelona and forced him to withdraw from Madrid quarter-finals earlier this month.
In Thursday's other quarter-final, Zverev eased past fifth-seed Steve Johnson 6-4 7-5 in a match that lasted an hour and 34 minutes.
(Reporting by Hardik Vyas in Bengaluru; editing by Mark Heinrich)
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