The top seed took just 65 minutes to dismiss Ram, boosting his chances of grabbing one of the eight spots for the year-ending ATP World Tour Finals in London.
The 24-year-old Japanese, ranked eighth in the world, defeated world number one Novak Djokovic in the semi-final at the U.S. Open but lost to Marin Cilic.
Nishikori will next take on Australian Marinko Matosevic in the quarter-finals of the hard-court tournament in the Malaysian capital.
(Writing by Sudipto Ganguly in Mumbai; editing by Clare Lovell)
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