Top-seeded Pablo Carreno Busta was knocked out of the Kremlin Cup in the second round by Daniil Medvedev 6-3 6-3 on Thursday.
The Russian broke 11th-ranked Carreno Busta twice in each set.
Medvedev's win sets up a quarter-final against Bosnian qualifier Mirza Basic.
Second-seeded Albert Ramos-Vinolas lost his second-round match in surprising style, beaten 4-6 7-5 6-2 by 107th-ranked Alexander Bublik, who fired in 19 aces.
The player from Kazakhstan had initially failed to qualify for the main draw but was given a place as a lucky loser.
Share
