On the eve of the Stamford Bridge tie, Chelsea assistant coach Gianfranco Zola hinted that Wilson was of "interest" to the London club, admitting he had all the attributes "to go a long way".
"Callum's our player and very, very focused on us. I think you could see that with his performance," Howe told reporters on Wednesday.
When asked whether there was any scenario in which Wilson could be sold in January, Howe replied: "Not from my perspective, no."
Bournemouth host Brighton and Hove Albion in a Premier League encounter on Saturday, hoping for a positive result after six defeats in seven matches has seen them slip to 11th place.
(Reporting by Hardik Vyas in Bengaluru; Editing by John O'Brien)
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