Malcolm Turnbull has shot down Pauline Hanson's assertion the government is blackmailing parents into vaccinating their children.
The prime minister says it's vital to the health of all Australians that close to the whole population be immunised.
"If parents choose not to vaccinate their children, they are putting their children's health at risk and every other person's children's health at risk too," he told reporters in central Queensland town Barcaldine on Sunday.
"It is a vital health objective to ensure that everybody is vaccinated."
Earlier, One Nation leader Senator Hanson questioned the effectiveness of vaccinations, urging parents to do their own research.
"If this having vaccinations and having measles vaccinations is actually going to stop these diseases, fine, no problems," she told ABC TV.
Health Minister Greg Hunt told AAP: "The clear and categorical advice from experts including the Chief Medical Officer, based on decades of research and evidence, is that vaccinations save lives."
Senator Hanson said the government was "blackmailing" people - a reference to the policy of withholding childcare fee rebates and welfare payments from parents who don't have their children fully immunised.
"Don't do that to people. That's a dictatorship," she said.
"I hear from so many parents, where are their rights?"
Mr Turnbull and Mr Hunt both highlighted the success of the "no jab no pay" policy, saying it had led to an extra 200,000 children being vaccinated over the past year.
"It's good news for kids, their families, and the community," Mr Hunt told AAP.
Labor's health spokeswoman Catherine King was appalled to hear Senator Hanson's comments.
"They aren't just wrong - they are dangerous," she wrote on Twitter.
Former Australian Medical Association president Brian Owler said Senator Hanson was "dangerous and ignorant".
"Vaccination (is) the most effective public health measure ever," the pediatric neurosurgeon wrote on Twitter.
Senator Hanson's advice was "uninformed, dangerous and insulting" and it was disgraceful that an Australian politician could endanger children like that, he said.
