Pakistan, replying to Sri Lanka's total of 320, were 6-244 in their first innings at stumps on Friday's second day of the second and final Test in Colombo.
Asad Shafiq made 42 and Sarfraz Ahmed was unbeaten on 66, the pair adding 93 for the sixth wicket after the tourists were reduced to 5-140 soon after tea.
Left-arm spinner Ranga Herath picked up 5-98 - his 20th five-wicket haul in Test matches.
Among his scalps were veteran batsman Younis Khan, caught behind for 13 to leave the tourists at 4-131, and captain Misbah-ul Haq who fell the same way for five (5-140).
The match is evenly balanced, Pakistan trailing by 76 runs with four wickets in hand.
Earlier, Sri Lanka were dismissed for 320, 45 minutes before lunch, after the last two wickets added 59 runs to the overnight score of 8-261.
Opener Upul Tharanga top-scored for Sri Lanka with 92.
Left-arm seamers Junaid Khan (5-87) and Wahab Riaz (3-88) shared eight wickets.
Sri Lanka won the first Test in Galle by seven wickets.
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