The 45-year-old Pampling moved to 20-under following round three at Thornblade Club on Saturday after opening with consecutive 9-under 63s at The Reserve at Lake Keowee and Green Valley Country Club.
"It's still foot down and I'm sure second is closer than it was yesterday," Pampling said.
"You can't take your foot off the accelerator. It's foot down the whole way and you just take advantage of good shots and I didn't do that today."
Mark Blakefield and Kelly Kraft are tied for second.
Blakefield had a 64 at Green Valley, and Kraft shot a 66 at Thornblade Club, the site of the final round.
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