Parisse had been a doubt after picking up a neck injury in Italy's opener -- a 33-7 home defeat by Wales last weekend -- but has been given the green light to face Joe Schmidt's side.
Ireland are also looking for their first win of the campaign after Saturday's 27-22 defeat by Scotland at Murrayfield.
O'Shea has brought experienced hooker Leonardo Ghiraldini into the front row at the expense of Ornel Gega, while Dries van Schalkwyk will start in the second row alongside Marco Fuser, taking the place of George Biagi.
Simone Favaro has also passed a fitness test and will start. The Glasgow Warriors openside flanker missed Italy's opener with shoulder and ankle injuries, and joins right wing Angelo Esposito -- named ahead of Giulio Bisegni -- in the starting lineup.
Italy: 15 Edoardo Padovani; 14 Angelo Esposito, 13 Tommaso Benvenuti, 12 Luke McLean, 11 Giovanbattista Venditti; 10 Carlo Canna, 9 Edoardo Gori; 1 Andrea Lovotti. 2 Leonardo Ghiraldini, 3 Lorenzo Cittadini, 4 Marco Fuser; 5 Dries van Schalkwyk, 6 Maxime Mbanda; 7 Simone Favaro, 8 Sergio Parisse (capt.)
Replacements: 16 Ornel Gega, 17 Sami Panico, 18 Dario Chistolini, 19 George Biagi, 20 Abraham Steyn, 21 Giorgio Bronzini, 22 Tommaso Allan, 23 Michele Campagnaro
(Reporting by Ed Dove; Editing by Toby Davis)
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