Tom Brady threw five touchdown passes and Brandon LaFell had a career high 11 catches as the New England Patriots hammered the Chicago Bears 51-23.
Brady, who was 30-of-35 for 354 passing yards, tossed touchdown strikes on five of the Patriots' first half dozen drives on Sunday.
Rob Gronkowski, who had to leave the game in the third quarter because of dehydration, had 149 yards on nine receptions and caught three of Brady's touchdown passes in the Patriots' win.
LaFell set career-highs for receptions and 124 receiving yards and had a touchdown catch for New England.
The Patriots won their fourth consecutive game and extended a home win streak to 13 games.
"It was good to see the whole team ready to go, playing with that kind of energy and execution," said New England coach Bill Belichick.
Bears quarterback Jay Cutler completed 20-of-30 passes for 227 yards with three touchdowns. Cutler also had a pair of turnovers.
Bears coach Marc Trestman said they would be doing a lot of soul searching.
"We have a whole half a season to play and we are going to go back tomorrow and start over and address every situation that we have and all aspects of our football team," he said.
Meanwhile the Bears' defensive end Lamarr Houston suffered a knee injury while after leaping into the air to celebrate a sack on Jimmy Garoppolo while his team was trailing by 35 points.
Brady and the Patriots must now get ready to face Peyton Manning's Denver Broncos at home next Sunday.
In Pittsburgh, Ben Roethlisberger carved up the Indianapolis Colts' defence for 522 yards and six touchdowns in the Pittsburgh Steelers' 51-34 victory. He finished just 32 yards short of Norm Van Brocklin's NFL record of 554, set in 1951.
Roethlisberger completed 40-of-49 passes to nine different receivers and matched Boomer Esiason for the fourth-most passing yards in a single game in league history.
In Charlotte, quarterback Russell Wilson rallied his team to a come-from-behind road win, firing a touchdown pass to Luke Willson with 47 seconds remaining to lift defending Super Bowl champs Seattle to a 13-9 victory over Carolina.
The Detroit Lions came from behind to beat the Atlanta Falcons 22-21 in London, England while New Orleans routed Green Bay 44-23.
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