Plane leaves South Pole with sick worker

A small plane has picked up a sick worker at the South Pole and is on its way to a British station on the Antarctic peninsula in a daring rescue.

US officials say a plane has landed in Antarctica to rescue a sick worker from a US science station. (AAP)

A small plane has left the South Pole with a sick worker in a daring rescue mission from the remote US science outpost.

National Science Foundation spokesman Peter West said on Wednesday the Canadian Twin Otter turboprop plane started the 2414km flight to Rothera, a British station on the Antarctic peninsula.

From there, the patient will be flown off Antarctica for medical attention that could not be provided on the remote continent.

West said at least one worker had to be evacuated, but it could be two.

Normally planes don't use the polar outpost from February to October because of the dangers of flying in the pitch dark and cold. On Wednesday it was minus 60C at the South Pole.