Plisson, who will earn his sixth cap after Camille Lopez was ruled out with a knee injury, will pair up with scrumhalf Sebastien Tillous-Borde while prop Vincent Debaty will start in place of Eddy Ben Arous, out with an arm muscle injury.
The rest of the team, who beat Italy 29-0 last Sunday, is unchanged.
Saint-Andre explained that it is Lopez's club, Clermont, who said the player needed a rest of up to six weeks.
"It is Clermont who decided Camille Lopez needed to be rested," the former France captain told a news conference on Thursday.
Plisson will start although he has a broken nose.
"He's got a broken nose but he is determined to play. He's OK for Saturday," said Saint-Andre.
France, fourth in the standings, opened their campaign with a victory against Scotland, then losing to Ireland and Wales before their Rome victory.
Team:
15-Scott Spedding, 14-Yoann Huget, 13-Gael Fickou, 12-Maxime Mermoz, 11-Noa Nakaitaci, 10-Jules Plisson, 9-Sebastien Tillous-Borde, 8-Loann Goujon, 7-Bernard Le Roux, 6-Thierry Dusautoir (captain), 5-Yoann Maestri, 4-Alexandre Flanquart, 3-Nicolas Mas, 2-Guilhem Guirado, 1-Vincent Debaty
Replacements:
16-Benjamin Kayser, 17-Rabah Slimani, 18-Uini Atonio, 19-Romain Taofifenua, 20-Damien Chouly, 21-Rory Kockott, 22-Remi Tales, 23-Mathieu Bastareaud
(Reporting by Julien Pretot; Editing by Sudipto Ganguly)
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