Spaniard Juan Mata starts in midfield while Marcus Rashford returns to the United starting line-up to make a three-pronged attack with Romelu Lukaku and Alexis Sanchez.
Defender Eric Bailly returned to the starting line-up after being sidelined for over three months with an injury.
Liverpool's Jordan Henderson, who suffered a dead-leg in Tuesday's Champions League tie against Porto, starts on the bench for Juergen Klopp's side.
Alex Oxlade-Chamberlain will partner Emre Can in the centre of midfield while James Milner captains the side in Henderson's absence.
(Reporting by Simon Evans, editing by Pritha Sarkar)
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