Police said the man pointed a handgun at an officer who approached him and another man at a gas station in the suburb of Berkeley.
"Fearing for his life, the Berkeley Officer fired several shots, striking the subject, fatally wounding him," St. Louis County Police Department spokesman Brian Schellman said in a statement.
Berkeley is minutes away from the suburb of Ferguson, where police officer Darren Wilson shot Michael Brown in August, a killing that ignited protests across the country against police methods.
About 200 people marched in New York on Tuesday, defying Mayor Bill de Blasio's call for protests to be suspended after two police officers were killed in their patrol car on Saturday in an apparent revenge attack.
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