Monaco had led through Mario Pasalic's 39th minute header from a corner but were reduced to 10 men midway through the second half when defender Wallace was red carded for a mistimed tackle on Ghezzal that sparked a brief skirmish.
The point lifted Lyon into fifth place with 16 points, above St Etienne on goal difference, two more than Monaco who remain in mid-table and are yet to win at home this season.
Unbeaten leaders Paris St Germain visit Bastia on Saturday while second-placed Angers are at Toulouse.
(Reporting by Martyn Herman; Editing by Ken Ferris)
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