"A fracture of the fifth metatarsal of his right foot has been detected. The player will have surgery in the following hours," read a statement on the Real website.
Rodriguez scored the opener in Real's 2-1 victory over Sevilla on Wednesday before going off injured.
Defender Sergio Ramos also had to be substituted with a hamstring problem and tests will take place to discover the extent of the injury.
With Pepe also injured and Marcelo suspended, coach Carlo Ancelotti faces a crisis in defence ahead of the crunch Madrid derby with Atletico on Saturday.
(Editing by Sudipto Ganguly)
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