Syrian government forces have captured more than a third of opposition-held eastern Aleppo , touching off a wave of panic and flight from the besieged enclave as rebel defenses in the country's largest city rapidly collapsed.
The dramatic gains mark an inflection point in Syria's nearly 6-year-old conflict, threatening to dislodge armed opponents of President Bashar Assad from their last major urban stronghold.
Reclaiming all of Aleppo, Syria's former commercial capital, would be the biggest prize of the war for Assad. It would put his forces in control of the country's four largest cities as well as the coastal region, and cap a year of steady government advances.
It also would bolster his position and momentum just as a new US administration is taking hold, freeing thousands of his troops and allied militiamen to move on to other battles around the country.
Helped by massive Russian air power and thousands of Iranian-backed Shiite militia fighters from Lebanon, Iraq and Iran, Assad renewed his push for Aleppo this month. The besieged eastern districts came under intense airstrikes that killed hundreds in the past two weeks.
More than 250,000 people are believed trapped there with limited access to food, water and medical supplies. They include more than 100,000 children, the UN says.
"It is stinging cold, food is scarce and people are shaken in the streets," Mohammad Zein Khandaqani, a member of the Medical Council in Aleppo, told The Associated Press in a text message from eastern Aleppo.
Some are taking refuge in mosques while others moved to homes of displaced people in safer areas, he added.
Thousands of civilians, many of whom had refused to leave despite the suffocating siege and bombardment that tested the limits of endurance, fled the enclave over the weekend and Monday.
The Syrian Arab Red Crescent (SARC) says it has registered 4000 people in the government-controlled Jibreen district of western Aleppo after they fled from the city's rebel-controlled eastern areas.
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